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NT-proANP has been shown to be a useful diagnostic and prognostic tool in heart failure and myocardial infarction. In patients with mild to moderate cardiac disease, NT-proANP levels were increased in response to atrial wall stress increase. Patients diagnosed with diastolic or systolic dysfunction had 2- to 3-fold higher NT-proANP than the control group (Berger et al., 2005; Volpe et al., 2015). Hulsmann and coworkers could demonstrate that NT-proANP appears to be a more sensitive marker than BNP or NT-proBNP with respect to the impact on survival in patients withchronic heart failure (Hülsmann et al., 2005). A study by Squire and co-workers showed that in patients following acute myocardial infarction NT-proBNP predicts 30-day and NT-proANP later than 30-day mortality (Squire et al., 2004). From this study the authors conclude that consideration of both, NT-proANP and NT-proBNP, identifies a greater number of patients at risk of death or heart failure than either peptide alone (Squire et al., 2004). Several studies successfully demonstrated that this NT-proANP ELISA is suitable for rat and cat samples and can be used in preclinical toxicology investigations (Colton et al., 2011; Dunn et al., 2017; Kim et al., 2016; Parzeniecka-Jaworska et al., 2016; Turner et al., 2018; Vinken et al., 2016; Zimmering et al., 2010). Vinken and colleagues demonstrated in a cross-laboratory analytical validation that this assay is technically adequate for the detection of NT-proANP serum levels in SD rats (Vinken et al., 2016). Numerous investigations have shown that NT-proANP is an excellent cardiovascular safety biomarker in rats (Dunn et al., 2017; Kim et al., 2016; Vinken et al., 2016).

PMID: 18203848Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD Registry.

Metastatic tumors to the brain affect nearly one in four patients with cancer, or an estimated 150,000 people a year. Up to 40 percent of people with lung cancer will develop metastatic brain tumors. In the past, the outcome for patients diagnosed with these tumors was very poor, with typical survival rates of just several weeks. More sophisticated diagnostic tools, in addition to innovative surgical and radiation approaches, have helped survival rates expand up to years; and also allowed for an improved quality of life for patients following diagnosis.

Chemotherapy generally is considered to be effective for specific pediatric tumors, lymphomas and some oligodendrogliomas. While it has been proven that chemotherapy improves overall survival in patients with the most malignant primary brain tumors, it does so in only in about 20 percent of all patients, and physicians cannot readily predict which patients will benefit before treatment. As such, some physicians choose not to use chemotherapy because of the potential side effects (lung scarring, suppression of the immune system, nausea, etc.).

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